KPV (5mg)

What is KPV (α-MSH 11-13)?

Just three amino acids but remarkable NF-κB inhibition — the master inflammatory switch.

Listed vial contents: 5mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.

What mechanisms are being studied?

KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of α-MSH. Despite being just three amino acids, it retains α-MSH's potent anti-inflammatory activity — primarily through direct inhibition of NF-κB nuclear translocation, the master transcriptional regulator of inflammation. It enters inflamed intestinal cells via the PepT1 transporter (upregulated in inflammation), creating a self-targeting system.

What are the research questions?

• Inflammatory bowel disease (IBD): The primary research focus. Studied extensively in ulcerative colitis and Crohn's disease models.
• Gut inflammation / leaky gut: Restores intestinal barrier integrity and reduces mucosal inflammation.
• Skin inflammation: Topical KPV studied for dermatitis, psoriasis, and wound healing.
• Antimicrobial: Direct antimicrobial activity against Staphylococcus aureus and Candida albicans.

What does the published work describe?

Brzoska T et al. (Endocr Rev 2008) — Comprehensive review of α-MSH/KPV anti-inflammatory mechanisms. Dalmasso G et al. (J Biol Chem 2008) — Oral KPV delivered via nanoparticles was as effective as injected anti-TNF antibodies in treating colitis in mice.

What are the limits of this evidence?

The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.

Study references

1. Brzoska T et al. Endocr Rev 2008
2. Dalmasso G et al. J Biol Chem 2008

These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.

How should I check lot documentation?

Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. Generated sample reports illustrate the reporting flow and are not evidence of testing, purity or accreditation.