Ecnoglutide (5mg/10mg)
cAMP-Biased Long-Acting GLP-1 Receptor Agonist
Ecnoglutide is listed for GLP-1 analog research. Catalog vial contents are 5mg / 10mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
Research Applications & Benefits
- Long-acting once-weekly GLP-1 analog
- cAMP-biased agonism profile
- Robust Phase 3 weight-loss & glycemic data
- Investigational obesity & T2D research tool
What is Ecnoglutide?
Ecnoglutide is a GLP-1 peptide analogue studied for cAMP-biased signaling. This catalog offers 5mg and 10mg research vials. Ecnoglutide is not mazdutide, whose development name is IBI362.
Listed vial contents: 5mg / 10mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.
What mechanisms are being studied?
Biased signaling means a molecule favors one receptor response relative to another. cAMP is an intracellular signaling molecule; beta-arrestin is a protein involved in receptor regulation. The bias depends on the assay and comparator, not only the compound name.
What are the research questions?
- cAMP signaling and beta-arrestin responses
- Assay-dependent receptor bias
- Separating signaling hypotheses from clinical glucose outcomes
What does the published work describe?
Zhu and colleagues' 2026 EECOH-1 paper describes a randomized, placebo-controlled phase 3 trial in adults with type 2 diabetes. It examined ecnoglutide monotherapy in a defined clinical preparation. Trial outcomes do not prove that receptor bias explains every observed effect or verify this supplied material.
Experimental models in the cited papers
- EECOH-1: randomized, double-blind phase 3 human type 2 diabetes trial
What could future research explore?
Matched cell assays can test the reproducibility of signaling bias. Future work should examine whether specific receptor responses explain clinical endpoints rather than assuming that a mechanistic hypothesis is established.
These are research directions, not established applications of the product sold here.
What are the limits of this evidence?
Clinical findings apply to the tested formulation, trial population and study conditions. They do not establish the identity, safety or effectiveness of this laboratory vial. Research Use Only: this material is not a finished medicine.
Study references
- Zhu D, et al. Efficacy and safety of cAMP signalling-biased GLP-1 analogue ecnoglutide monotherapy versus placebo in patients with type 2 diabetes (EECOH-1): a multi-centre, randomised, double-blind, placebo-controlled, phase 3 trial. Nat Commun. 2026. PMID 41501026
How should I check lot documentation?
Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.
How is Ecnoglutide handled in the lab?
For Ecnoglutide, record the product code ECNO-10, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
Choose a solvent for Ecnoglutide from the documented sequence or chemical identity, salt form and assay requirements. Test a small portion first and record pH, solvent composition and clarity. Do not assume one diluent works for every research material; include a solvent-only control and establish compatibility before using the stock in an assay.
For Ecnoglutide, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; the catalog lists ~4400 g/mol as a reference, not lot confirmation. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
Use the documented storage conditions for the supplied Ecnoglutide form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
A Ecnoglutide laboratory protocol should record identity, product code ECNO-10, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Research Use Only. Not for human consumption, therapeutic, veterinary or any in-vivo use.
Product Specifications
- Compound
- Ecnoglutide
- CAS Number
- 2247478-50-2
- Molecular Weight
- ~4400 g/mol
- HPLC Purity Specification
- ≥99%
- Category
- GLP-1 & Metabolic
- Starting Price
- $149.00 USD
- Country of Origin
- United States
- Shipping
- Cold-chain insulated packaging, fast domestic delivery
- Payment
- Card, ACH, and cryptocurrency (10% discount)
Quality & Verification
Ecnoglutide has a catalog purity specification of ≥99%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
Frequently Asked Questions
What is Ecnoglutide?
Ecnoglutide is listed for GLP-1 analog research. Catalog vial contents are 5mg / 10mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
What strengths of Ecnoglutide are available?
The catalog lists 5mg / 10mg. These labels describe vial contents, not administration doses. Select the required strength for current pricing and availability; match analysis records to that exact strength and lot.
How should I interpret Ecnoglutide purity results?
Ecnoglutide has a catalog purity specification of ≥99%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
How should Ecnoglutide be handled in the laboratory?
For Ecnoglutide, record the product code ECNO-10, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
How do I choose a laboratory solvent for Ecnoglutide?
Choose a solvent for Ecnoglutide from the documented sequence or chemical identity, salt form and assay requirements. Test a small portion first and record pH, solvent composition and clarity. Do not assume one diluent works for every research material; include a solvent-only control and establish compatibility before using the stock in an assay.
How do I calculate a Ecnoglutide stock concentration?
For Ecnoglutide, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; the catalog lists ~4400 g/mol as a reference, not lot confirmation. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
How should Ecnoglutide be stored after preparation?
Use the documented storage conditions for the supplied Ecnoglutide form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
What should a Ecnoglutide lab protocol document?
A Ecnoglutide laboratory protocol should record identity, product code ECNO-10, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Does Fmoc or Boc synthesis explain this Ecnoglutide product?
Fmoc and Boc are peptide protecting-group strategies, not proof of how this Ecnoglutide lot was made. For sequence-defined peptides, synthesis review can examine deletion products, incomplete deprotection and modifications using the method and matching analytical evidence. A single chromatographic peak does not by itself establish sequence.
Is Ecnoglutide for human use?
No. Ecnoglutide is strictly Research Use Only. It is not intended for human or veterinary use, diagnosis or treatment. Laboratory handling guidance is not an administration protocol.
Research Use Only. This product is intended for licensed laboratory research and is not for human or veterinary use.
