SS-31 (25mg/50mg)

What is SS-31 (Elamipretide)?

Stabilizes cardiolipin in the mitochondrial inner membrane, repairing core energy production.

Listed vial contents: 25mg / 50mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.

What mechanisms are being studied?

SS-31 (D-Arg-Dmt-Lys-Phe-NH2) is a cell-permeable tetrapeptide that concentrates 5,000-fold in mitochondria, specifically binding to cardiolipin on the inner mitochondrial membrane. Cardiolipin is essential for electron transport chain complex organization and ATP production. SS-31 stabilizes cardiolipin-cytochrome c interactions and prevents cardiolipin peroxidation.

What are the research questions?

• Heart failure: EMBRACE trial showed improved left ventricular volumes. FDA orphan drug and fast-track designations.
• Barth syndrome: FDA breakthrough therapy designation for this rare mitochondrial disease. TAZPOWER trial showed improved cardiac and skeletal muscle function.
• Primary mitochondrial myopathy: Studied for restoration of muscle function in genetic mitochondrial diseases.
• Age-related mitochondrial decline: Reverses mitochondrial dysfunction associated with aging in preclinical models.
• Kidney disease: Renoprotective effects through improved mitochondrial function in renal tubular cells.

What does the published work describe?

Szeto HH (AAPS J 2006) — 5,000-fold mitochondrial concentration, cardiolipin stabilization confirmed. EMBRACE trial — Improved LV volumes in heart failure. TAZPOWER — Improved 6-minute walk distance in Barth syndrome. FDA orphan drug, fast-track, and breakthrough therapy designations.

What are the limits of this evidence?

The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.

Study references

1. Szeto HH. AAPS J 2006

These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.

How should I check lot documentation?

Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.

How is SS-31 (Elamipretide) handled in the lab?

Plan a SS-31 (Elamipretide) stock solution from the sequence, the listed molecular weight (640.8 g/mol) and, when reported for the same lot, net peptide content. Test-dissolve a small portion first, store the powder sealed, cold and dry, and split solutions into single-use aliquots. These are laboratory handling notes, not administration guidance.

• Peptide solubility: choosing a lab solvent
• Stock solution molarity and concentration math
• Lyophilized storage, aliquoting and freeze-thaw
• Fmoc vs Boc synthesis and the impurities they leave