PNC-27 (5mg)
Cancer Cell Selective Peptide
Order PNC-27 (5mg) online for laboratory research. Compare the listed vial options and current price, then add your selection to cart and continue to checkout. Review available COA records for the exact product, strength and lot. Research Use Only; not for human or veterinary use.
PNC-27 is listed for specialty laboratory research. Catalog vial contents are 5mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
Research Applications & Benefits
- Selectively targets cancer cells
- Spares normal cells
- Unique cytotoxicity
What is PNC-27?
Binds HDM-2 on cancer cell surfaces, causing selective destruction.
Listed vial contents: 5mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.
What mechanisms are being studied?
PNC-27 binds to HDM-2 protein when aberrantly expressed on the surface of cancer cells. Normal cells express HDM-2 intracellularly; cancer cells uniquely express it on their outer membrane. Upon binding surface HDM-2, PNC-27 creates membrane pores causing rapid and selective cancer cell lysis while leaving normal cells unharmed.
What are the research questions?
- Cancer research: Selective cytotoxicity against cancer cells expressing surface HDM-2 — studied in pancreatic, breast, leukemia, and melanoma cell lines.
- Tumor targeting: Selectivity for cancer cells via surface HDM-2 provides potential for tumor destruction without collateral damage.
What does the published work describe?
Kanovsky M et al. (PNAS 2001) — Rapid and specific killing of cancer cells expressing surface HDM-2. Sarafraz-Yazdi E et al. — Selective destruction of pancreatic, breast, and leukemia cells while sparing normal cells.
What are the limits of this evidence?
The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.
Study references
- Kanovsky M et al. PNAS 2001
These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.
How should I check lot documentation?
Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.
How is PNC-27 handled in the lab?
For PNC-27, record the product code PNC27, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
Choose a solvent for PNC-27 from the documented sequence or chemical identity, salt form and assay requirements. Test a small portion first and record pH, solvent composition and clarity. Do not assume one diluent works for every research material; include a solvent-only control and establish compatibility before using the stock in an assay.
For PNC-27, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; no usable molecular weight is established by the blank catalog field. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
Use the documented storage conditions for the supplied PNC-27 form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
A PNC-27 laboratory protocol should record identity, product code PNC27, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Research Use Only. Not for human consumption, therapeutic, veterinary or any in-vivo use.
Product Specifications
- Compound
- PNC-27
- CAS Number
- Molecular Weight
- HPLC Purity Specification
- ≥98%
- Category
- Specialty
- Starting Price
- $89.00 USD
- Country of Origin
- United States
- Shipping
- Cold-chain insulated packaging, fast domestic delivery
- Payment
- Card, ACH, and cryptocurrency (10% discount)
Quality & Verification
PNC-27 has a catalog purity specification of ≥98%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
Frequently Asked Questions
What is PNC-27?
PNC-27 is listed for specialty laboratory research. Catalog vial contents are 5mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
What strengths of PNC-27 are available?
The catalog lists 5mg. These labels describe vial contents, not administration doses. Select the required strength for current pricing and availability; match analysis records to that exact strength and lot.
How should I interpret PNC-27 purity results?
PNC-27 has a catalog purity specification of ≥98%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
How should PNC-27 be handled in the laboratory?
For PNC-27, record the product code PNC27, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
How do I choose a laboratory solvent for PNC-27?
Choose a solvent for PNC-27 from the documented sequence or chemical identity, salt form and assay requirements. Test a small portion first and record pH, solvent composition and clarity. Do not assume one diluent works for every research material; include a solvent-only control and establish compatibility before using the stock in an assay.
How do I calculate a PNC-27 stock concentration?
For PNC-27, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; no usable molecular weight is established by the blank catalog field. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
How should PNC-27 be stored after preparation?
Use the documented storage conditions for the supplied PNC-27 form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
What should a PNC-27 lab protocol document?
A PNC-27 laboratory protocol should record identity, product code PNC27, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Does Fmoc or Boc synthesis explain this PNC-27 product?
Fmoc and Boc are peptide protecting-group strategies, not proof of how this PNC-27 lot was made. For sequence-defined peptides, synthesis review can examine deletion products, incomplete deprotection and modifications using the method and matching analytical evidence. A single chromatographic peak does not by itself establish sequence.
Is PNC-27 for human use?
No. PNC-27 is strictly Research Use Only. It is not intended for human or veterinary use, diagnosis or treatment. Laboratory handling guidance is not an administration protocol.
Research Use Only. This product is intended for licensed laboratory research and is not for human or veterinary use.
