PNC-27 (5mg)
Cancer Cell Selective Peptide
Binds HDM-2 on cancer cell surfaces, causing selective destruction.
Research Applications & Benefits
- Selectively targets cancer cells
- Spares normal cells
- Unique cytotoxicity
What is PNC-27?
Binds HDM-2 on cancer cell surfaces, causing selective destruction.
Listed vial contents: 5mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.
What mechanisms are being studied?
PNC-27 binds to HDM-2 protein when aberrantly expressed on the surface of cancer cells. Normal cells express HDM-2 intracellularly; cancer cells uniquely express it on their outer membrane. Upon binding surface HDM-2, PNC-27 creates membrane pores causing rapid and selective cancer cell lysis while leaving normal cells unharmed.
What are the research questions?
- Cancer research: Selective cytotoxicity against cancer cells expressing surface HDM-2 — studied in pancreatic, breast, leukemia, and melanoma cell lines.
- Tumor targeting: Selectivity for cancer cells via surface HDM-2 provides potential for tumor destruction without collateral damage.
What does the published work describe?
Kanovsky M et al. (PNAS 2001) — Rapid and specific killing of cancer cells expressing surface HDM-2. Sarafraz-Yazdi E et al. — Selective destruction of pancreatic, breast, and leukemia cells while sparing normal cells.
What are the limits of this evidence?
The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.
Study references
- Kanovsky M et al. PNAS 2001
These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.
How should I check lot documentation?
Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. Generated sample reports illustrate the reporting flow and are not evidence of testing, purity or accreditation.
Research Use Only. Not for human consumption, therapeutic, veterinary or any in-vivo use.
Product Specifications
- Compound
- PNC-27
- CAS Number
- Molecular Weight
- HPLC Purity Specification
- ≥98%
- Category
- Specialty
- Starting Price
- $89.00 USD
- Country of Origin
- United States
- Shipping
- Cold-chain insulated packaging, fast domestic delivery
- Payment
- Card, ACH, and cryptocurrency (10% discount)
Quality & Verification
PNC-27 carries the purity specification shown above. Where a lot-specific CertikLabs Certificate of Analysis is available, the product page links its HPLC purity, LC-MS identity, and concentration results.
Frequently Asked Questions
Is PNC-27 suitable for human consumption?
No. PNC-27 is sold strictly for in-vitro laboratory research. It is not a drug, supplement, cosmetic, or food product and must not be administered to humans or animals.
What purity is PNC-27?
PNC-27 carries a ≥98% HPLC purity specification. Check the product page for an available lot report.
How is PNC-27 shipped and stored?
Vials are shipped lyophilized in temperature-controlled packaging. Store unopened lyophilized peptide at −20°C; once reconstituted with bacteriostatic water, store at 2–8°C and use within 28 days.
Research Use Only. This product is intended for licensed laboratory research and is not for human or veterinary use.
