PEG-MOTS-c (10mg)

What is PEG-MOTS-c?

A polyethylene-glycol-conjugated form of MOTS-c, engineered for slower clearance and sustained mitokine signaling.

Listed vial contents: 10mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.

What mechanisms are being studied?

PEG-MOTS-c is MOTS-c (mitochondrial open-reading-frame of the twelve S rRNA-c) conjugated to a polyethylene-glycol moiety to reduce renal clearance and proteolytic degradation. The native MOTS-c sequence activates AMPK, increases insulin sensitivity, and promotes mitochondrial biogenesis through PGC-1α; PEGylation extends systemic exposure several-fold.

What are the research questions?

• Mitokine research: Extended pharmacokinetic profile useful in chronic mitochondrial-signaling studies.
• Metabolic and longevity models: Used in rodent studies of healthspan, insulin sensitivity, and skeletal-muscle oxidative capacity.
• Exercise-mimetic research: Investigated as a long-acting alternative to native MOTS-c in endurance models.

What does the published work describe?

Native MOTS-c pharmacology established by Lee C et al. (Cell Metab 2015). PEGylated extensions follow standard PEG-conjugation pharmacology — extended T1/2 and reduced peak concentrations vs the parent peptide. No published human trials.

What are the limits of this evidence?

The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.

Study references

1. Lee C et al. Cell Metab 2015 — MOTS-c
2. Kim KH et al. Aging Cell 2018

These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.

How should I check lot documentation?

Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.

How is PEG-MOTS-c handled in the lab?

Plan a PEG-MOTS-c stock solution from the sequence, the listed molecular weight (~6000 g/mol) and, when reported for the same lot, net peptide content. Test-dissolve a small portion first, store the powder sealed, cold and dry, and split solutions into single-use aliquots. These are laboratory handling notes, not administration guidance.

• Peptide solubility: choosing a lab solvent
• Stock solution molarity and concentration math
• Lyophilized storage, aliquoting and freeze-thaw
• Fmoc vs Boc synthesis and the impurities they leave