PE-22-28 (8mg)
Novel Rapid-Acting Antidepressant Compound
Order PE-22-28 (8mg) online for laboratory research with US shipping options at checkout. Compare the listed vial options and current price, then add your selection to cart and continue to checkout. Review available COA records for the exact product, strength and lot. Research Use Only; not for human or veterinary use.
PE-22-28 is listed for specialty laboratory research. Catalog vial contents are 8mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
Buy PE-22-28 online with US shipping
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PE-22-28 shipping to New York, NY
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PE-22-28 shipping to Los Angeles, CA
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PE-22-28 shipping to Chicago, IL
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PE-22-28 shipping to Houston, TX
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PE-22-28 shipping to Phoenix, AZ
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PE-22-28 shipping to Miami, FL
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PE-22-28 shipping to Atlanta, GA
Ordering for a research address in Atlanta? Select your vial strength above, review its available analysis records, then choose Buy Now. Shipping options and cost are confirmed for your address at checkout; the standard domestic estimate is not a city-specific arrival guarantee.
PE-22-28 shipping to Seattle, WA
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Research Applications & Benefits
- TREK-1 channel antagonist
- Rapid antidepressant effects
- Promotes neurogenesis
What is PE-22-28?
PE-22-28 is a seven-residue shortened analogue derived from the sortilin-propeptide sequence. It differs from longer spadin, PE-12-28.
Listed vial contents: 8mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.
What mechanisms are being studied?
Djillani and colleagues examined shortened analogues through electrophysiology in cells expressing human TREK-1 and behavioral experiments in mice. TREK-1 is an ion channel; channel inhibition and animal behavior are different levels of evidence.
What are the research questions?
- TREK-1 electrophysiology
- Shortened versus parent spadin constructs
- Terminal modifications and response persistence
What does the published work describe?
The direct 2017 study supports construct-specific TREK-1 research and antidepressant-like mouse observations. It does not demonstrate treatment of human depression or a clinical advantage over another compound.
Experimental models in the cited papers
- Engineered-cell electrophysiology and mouse behavioral studies
What could future research explore?
Matched experiments could compare each shortened or terminally modified analogue independently. Parent spadin results and knockout-animal observations should not be assigned automatically to PE-22-28.
These are research directions, not established applications of the product sold here.
What are the limits of this evidence?
Animal behavioral labels are not clinical diagnoses or treatment outcomes. Exact construct matching is necessary before comparing persistence or neurogenesis claims.
Study references
How should I check lot documentation?
Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.
How is PE-22-28 handled in the lab?
For PE-22-28, record the product code PE22, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
Choose a solvent for PE-22-28 from the documented sequence or chemical identity, salt form and assay requirements. Test a small portion first and record pH, solvent composition and clarity. Do not assume one diluent works for every research material; include a solvent-only control and establish compatibility before using the stock in an assay.
For PE-22-28, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; no usable molecular weight is established by the blank catalog field. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
Use the documented storage conditions for the supplied PE-22-28 form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
A PE-22-28 laboratory protocol should record identity, product code PE22, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Research Use Only. Not for human consumption, therapeutic, veterinary or any in-vivo use.
Product Specifications
- Compound
- PE-22-28
- CAS Number
- Molecular Weight
- HPLC Purity Specification
- ≥98%
- Category
- Specialty
- Starting Price
- $89.00 USD
- Country of Origin
- United States
- Shipping
- Cold-chain insulated packaging, fast domestic delivery
- Payment
- Card, ACH, and cryptocurrency (10% discount)
Quality & Verification
PE-22-28 has a catalog purity specification of ≥98%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
Frequently Asked Questions
What is PE-22-28?
PE-22-28 is listed for specialty laboratory research. Catalog vial contents are 8mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
What strengths of PE-22-28 are available?
The catalog lists 8mg. These labels describe vial contents, not administration doses. Select the required strength for current pricing and availability; match analysis records to that exact strength and lot.
How should I interpret PE-22-28 purity results?
PE-22-28 has a catalog purity specification of ≥98%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
How should PE-22-28 be handled in the laboratory?
For PE-22-28, record the product code PE22, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
How do I choose a laboratory solvent for PE-22-28?
Choose a solvent for PE-22-28 from the documented sequence or chemical identity, salt form and assay requirements. Test a small portion first and record pH, solvent composition and clarity. Do not assume one diluent works for every research material; include a solvent-only control and establish compatibility before using the stock in an assay.
How do I calculate a PE-22-28 stock concentration?
For PE-22-28, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; no usable molecular weight is established by the blank catalog field. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
How should PE-22-28 be stored after preparation?
Use the documented storage conditions for the supplied PE-22-28 form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
What should a PE-22-28 lab protocol document?
A PE-22-28 laboratory protocol should record identity, product code PE22, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Does Fmoc or Boc synthesis explain this PE-22-28 product?
Fmoc and Boc are peptide protecting-group strategies, not proof of how this PE-22-28 lot was made. For sequence-defined peptides, synthesis review can examine deletion products, incomplete deprotection and modifications using the method and matching analytical evidence. A single chromatographic peak does not by itself establish sequence.
Is PE-22-28 for human use?
No. PE-22-28 is strictly Research Use Only. It is not intended for human or veterinary use, diagnosis or treatment. Laboratory handling guidance is not an administration protocol.
Research Use Only. This product is intended for licensed laboratory research and is not for human or veterinary use.
