FGL (10mg)

What is FGL (FGLL)?

A 15-amino-acid mimetic of the neural cell adhesion molecule (NCAM) FG loop that activates FGFR1 signaling.

Listed vial contents: 10mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.

What mechanisms are being studied?

FGL (also FGLL) is a synthetic 15-amino-acid peptide derived from the second fibronectin type-III module of NCAM. It binds and activates fibroblast growth factor receptor 1 (FGFR1), triggering MAPK signaling that supports neurite outgrowth, long-term potentiation, and dendritic-spine remodeling. It also exhibits anti-inflammatory activity in CNS microglia.

What are the research questions?

• Cognitive aging research: Improved memory and LTP in aged rat models.
• Neurodegeneration models: Protective against amyloid-β and oxidative neuronal injury.
• Alcohol-related neurotoxicity: Restored hippocampal function in chronic ethanol exposure paradigms.
• Anti-inflammatory neuroscience: Reduced microglial activation in neuroinflammation models.

What does the published work describe?

Cambon K et al. (J Neurosci 2004) — improved spatial learning and LTP in aged rats. Klementiev B et al. — neuroprotective against Aβ25-35 toxicity. BBB permeability confirmed in rodent PK studies.

What are the limits of this evidence?

The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.

Study references

1. Cambon K et al. J Neurosci 2004
2. Klementiev B et al. Neuroscience 2007

These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.

How should I check lot documentation?

Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.

How is FGL (FGLL) handled in the lab?

Plan a FGL (FGLL) stock solution from the sequence, the listed molecular weight (1639.85 g/mol) and, when reported for the same lot, net peptide content. Test-dissolve a small portion first, store the powder sealed, cold and dry, and split solutions into single-use aliquots. These are laboratory handling notes, not administration guidance.

• Peptide solubility: choosing a lab solvent
• Stock solution molarity and concentration math
• Lyophilized storage, aliquoting and freeze-thaw
• Fmoc vs Boc synthesis and the impurities they leave