Argireline (10mg)

What is Argireline (Acetyl Hexapeptide-8)?

A six-amino-acid mimetic of the SNAP-25 N-terminus, frequently studied in topical formulations for the appearance of expression lines.

Listed vial contents: 10mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.

What mechanisms are being studied?

Argireline (Acetyl Hexapeptide-8, sequence Ac-EEMQRR-NH2) is patterned after the N-terminal portion of SNAP-25, a component of the SNARE complex required for acetylcholine vesicle docking and release. By competing with SNAP-25, it modestly attenuates the SNARE assembly that triggers muscle-fiber contraction in cultured neuromuscular models.

What are the research questions?

• Topical cosmetic research: Used in vitro and in clinical cosmetic studies investigating expression-line appearance.
• SNARE complex biology: A research probe for vesicular release pharmacology.
• Comparator compound: Used alongside botulinum toxin systems in mechanistic comparisons.

What does the published work describe?

Blanes-Mira C et al. (Int J Cosmet Sci 2002) — reduced wrinkle depth by ~30% over 30 days in a small topical study. Subsequent independent trials report smaller effect sizes. Skin penetration is the dominant limiting factor.

What are the limits of this evidence?

The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.

Study references

1. Blanes-Mira C et al. Int J Cosmet Sci 2002
2. Wang Y et al. J Cosmet Dermatol 2013

These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.

How should I check lot documentation?

Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.

How is Argireline (Acetyl Hexapeptide-8) handled in the lab?

Plan a Argireline (Acetyl Hexapeptide-8) stock solution from the sequence, the listed molecular weight (888.99 g/mol) and, when reported for the same lot, net peptide content. Test-dissolve a small portion first, store the powder sealed, cold and dry, and split solutions into single-use aliquots. These are laboratory handling notes, not administration guidance.

• Peptide solubility: choosing a lab solvent
• Stock solution molarity and concentration math
• Lyophilized storage, aliquoting and freeze-thaw
• Fmoc vs Boc synthesis and the impurities they leave