5-Amino-1MQ (50mg/100mg)

What is 5-Amino-1MQ?

Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). Studied for adipose-specific metabolic reprogramming and sarcopenia.

Listed vial contents: 50mg / 100mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.

What mechanisms are being studied?

5-Amino-1MQ is a cell-permeable, selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT consumes S-adenosyl methionine (SAM) and methylates nicotinamide, depleting both methyl-donor capacity and NAD+ precursors in adipose tissue. Inhibiting NNMT preserves SAM, restores NAD+ availability, and increases energy expenditure in adipocytes.

What are the research questions?

• Adipose metabolic research: Reduced fat mass and improved insulin sensitivity in diet-induced obese mice without changes in food intake.
• Muscle stem cell regeneration: Neelakantan et al. (2019) demonstrated improved muscle stem cell function and accelerated repair in aged mice.
• Healthspan research: Of interest for sarcopenia and age-related metabolic decline.

What does the published work describe?

Kannt A et al. Neelakantan H et al. (Biochem Pharmacol 2019) — restored muscle regeneration in aged mice. No published human trials to date.

What are the limits of this evidence?

The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.

Study references

1. Kannt A et al. Sci Rep 2018;8:3660
2. Neelakantan H et al. Biochem Pharmacol 2019

These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.

How should I check lot documentation?

Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.

How is 5-Amino-1MQ handled in the lab?

Plan a 5-Amino-1MQ stock solution from the sequence, the listed molecular weight (159.19 g/mol) and, when reported for the same lot, net peptide content. Test-dissolve a small portion first, store the powder sealed, cold and dry, and split solutions into single-use aliquots. These are laboratory handling notes, not administration guidance.

• Peptide solubility: choosing a lab solvent
• Stock solution molarity and concentration math
• Lyophilized storage, aliquoting and freeze-thaw
• Fmoc vs Boc synthesis and the impurities they leave