AICAR (50mg)

What is AICAR?

Activates AMPK, a cellular energy sensor studied in fatty-acid oxidation and mitochondria production.

Listed vial contents: 50mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.

What mechanisms are being studied?

AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) directly activates AMP-activated protein kinase (AMPK) — a central cellular energy sensor. AMPK activation triggers the same metabolic cascades produced by exercise: increased fatty acid oxidation, mitochondrial biogenesis, glucose uptake, and autophagy. AICAR bypasses the need for actual energy depletion (exercise) to activate these pathways.

What are the research questions?

• Exercise mimetic research: The defining 'exercise-in-a-pill' compound. Used extensively to study what happens when exercise signaling pathways are activated without physical activity.
• Metabolic syndrome / insulin resistance: AMPK activation improves insulin sensitivity, glucose uptake, and fatty acid oxidation.
• Cardiac ischemia: Has shown cardioprotective effects by pre-conditioning cells via AMPK, improving survival after ischemic events.
• Performance research: WADA banned AICAR in 2011 due to endurance-enhancing potential.

What does the published work describe?

Narkar VA et al. (Cell 2008) — 44% improvement in running endurance in sedentary mice treated for 4 weeks. Enhanced expression of oxidative metabolism genes identical to those activated by exercise training. Merrill GF et al. (1997) — AICAR improved cardiac output and reduced infarct size in ischemia models.

What are the limits of this evidence?

The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.

Study references

1. Narkar VA et al. Cell 2008;134(3):405-415
2. Merrill GF et al. Am J Physiol 1997

These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.

How should I check lot documentation?

Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. Generated sample reports illustrate the reporting flow and are not evidence of testing, purity or accreditation.