AICAR (50mg)
The Exercise-in-a-Molecule Research Compound
Order AICAR (50mg) online for laboratory research. Compare the listed vial options and current price, then add your selection to cart and continue to checkout. Review available COA records for the exact product, strength and lot. Research Use Only; not for human or veterinary use.
AICAR is listed for glp-1 & metabolic laboratory research. Catalog vial contents are 50mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
Research Applications & Benefits
- Activates central energy sensor
- Mimics cellular exercise
- Stimulates mitochondria production
- Exercise science research tool
What is AICAR?
Activates AMPK, a cellular energy sensor studied in fatty-acid oxidation and mitochondria production.
Listed vial contents: 50mg. These are supplied quantities, not administration doses. Current pricing and availability are shown in the strength selector.
What mechanisms are being studied?
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) directly activates AMP-activated protein kinase (AMPK) — a central cellular energy sensor. AMPK activation triggers the same metabolic cascades produced by exercise: increased fatty acid oxidation, mitochondrial biogenesis, glucose uptake, and autophagy. AICAR bypasses the need for actual energy depletion (exercise) to activate these pathways.
What are the research questions?
- Exercise mimetic research: The defining 'exercise-in-a-pill' compound. Used extensively to study what happens when exercise signaling pathways are activated without physical activity.
- Metabolic syndrome / insulin resistance: AMPK activation improves insulin sensitivity, glucose uptake, and fatty acid oxidation.
- Cardiac ischemia: Has shown cardioprotective effects by pre-conditioning cells via AMPK, improving survival after ischemic events.
- Performance research: WADA banned AICAR in 2011 due to endurance-enhancing potential.
What does the published work describe?
Narkar VA et al. (Cell 2008) — 44% improvement in running endurance in sedentary mice treated for 4 weeks. Enhanced expression of oxidative metabolism genes identical to those activated by exercise training. Merrill GF et al. (1997) — AICAR improved cardiac output and reduced infarct size in ischemia models.
What are the limits of this evidence?
The research described concerns the cited experimental materials and models, not proof that this supplied vial is a treatment. Cell or animal findings do not establish human benefits. Clinical findings, where cited, apply to the tested formulation and population; they do not validate this research product for human use.
Study references
- Narkar VA et al. Cell 2008;134(3):405-415
- Merrill GF et al. Am J Physiol 1997
These are the catalog's existing bibliographic references. No new source verification is implied by this presentation.
How should I check lot documentation?
Match the product, strength and lot to an original analysis document. Literature describes experimental findings; it does not verify the contents of this inventory. A report is evidence only for the product, strength and lot it names.
How is AICAR handled in the lab?
For AICAR, record the product code AICAR-50, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
AICAR is not a peptide. Select solvent, pH and working conditions from documentation for the specific chemical form and the assay, not a generic peptide reconstitution recipe. Test a small portion, check for precipitation after dilution into assay medium and include vehicle controls.
For AICAR, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; the catalog lists 338.21 g/mol as a reference, not lot confirmation. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
Use the documented storage conditions for the supplied AICAR form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
A AICAR laboratory protocol should record identity, product code AICAR-50, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Research Use Only. Not for human consumption, therapeutic, veterinary or any in-vivo use.
Product Specifications
- Compound
- AICAR
- CAS Number
- 2627-69-2
- Molecular Weight
- 338.21 g/mol
- HPLC Purity Specification
- ≥99%
- Category
- GLP-1 & Metabolic
- Starting Price
- $69.00 USD
- Country of Origin
- United States
- Shipping
- Cold-chain insulated packaging, fast domestic delivery
- Payment
- Card, ACH, and cryptocurrency (10% discount)
Quality & Verification
AICAR has a catalog purity specification of ≥99%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
Frequently Asked Questions
What is AICAR?
AICAR is listed for glp-1 & metabolic laboratory research. Catalog vial contents are 50mg; select the required strength before ordering. This material is supplied for Research Use Only, not as a medicine or a product for human or veterinary use.
What strengths of AICAR are available?
The catalog lists 50mg. These labels describe vial contents, not administration doses. Select the required strength for current pricing and availability; match analysis records to that exact strength and lot.
How should I interpret AICAR purity results?
AICAR has a catalog purity specification of ≥99%; this is not a measured result for every vial. Match the product, exact strength, batch and lot to its analysis record and read only the reported fields. HPLC peak-area purity, measured content and endotoxin are separate measurements. A blank field means no result is reported, not zero or passed. A purity percentage alone does not establish identity, sterility or suitability for human use.
How should AICAR be handled in the laboratory?
For AICAR, record the product code AICAR-50, selected strength and lot before opening. Follow the material-specific safety data sheet and laboratory SOP, with appropriate gloves, eye protection and containment. For a documented dry preparation, let the sealed vial equilibrate before opening to reduce condensation; minimize time open and use clean, compatible vessels.
How do I choose a laboratory solvent for AICAR?
AICAR is not a peptide. Select solvent, pH and working conditions from documentation for the specific chemical form and the assay, not a generic peptide reconstitution recipe. Test a small portion, check for precipitation after dilution into assay medium and include vehicle controls.
How do I calculate a AICAR stock concentration?
For AICAR, calculate mass concentration as measured material mass divided by final solution volume. Calculate molarity only with a documented molecular weight for the supplied chemical form; the catalog lists 338.21 g/mol as a reference, not lot confirmation. Where available, use matched-lot net content rather than treating chromatographic purity as a mass correction. Record both stock concentration and subsequent dilution factors.
How should AICAR be stored after preparation?
Use the documented storage conditions for the supplied AICAR form and lot. For a documented lyophilized preparation, keep the vial sealed and protected from moisture; for solutions, validate temperature, light exposure and holding time in the assay. Use compatible single-use aliquots when appropriate to reduce repeated freeze-thaw. No universal temperature or 28-day solution shelf life is established by the catalog name.
What should a AICAR lab protocol document?
A AICAR laboratory protocol should record identity, product code AICAR-50, strength, lot, applicable analysis results, solvent and pH, stock concentration, dilution sequence, vessel type, storage history and assay endpoints. Include vehicle and reference controls, independent replicates and predefined acceptance criteria. Separate handling validation from biological interpretation; these notes do not provide administration or dosing instructions.
Does Fmoc or Boc synthesis explain this AICAR product?
AICAR is a non-peptide research material; Fmoc/Boc peptide synthesis is not its default manufacturing model. Review compound-specific identity and impurity methods rather than assigning peptide sequence or synthesis claims to this product.
Is AICAR for human use?
No. AICAR is strictly Research Use Only. It is not intended for human or veterinary use, diagnosis or treatment. Laboratory handling guidance is not an administration protocol.
Research Use Only. This product is intended for licensed laboratory research and is not for human or veterinary use.
