CJC-1295 vs Ipamorelin: and why they're paired
CJC-1295 vs ipamorelin comes down to two receptors: CJC-1295 is a modified GHRH analog, while ipamorelin is a ghrelin-receptor agonist. Because they stimulate growth hormone through separate pathways, the CJC-1295/Ipamorelin combination is one of the most studied research blends. CJC-1295 with DAC binds albumin and lasts for days; the no-DAC form (used in our blend) acts for a much shorter time. All forms here are supplied for laboratory research use only.
Side-by-side comparison
| CJC-1295 | Ipamorelin | |
|---|---|---|
| Class | GHRH analog | Ghrelin-receptor agonist (GHRP) |
| Receptor | GHRH receptor | GHS-R1a |
| Length | 30 amino acids (modified GHRH 1-29) | 5 amino acids |
| Duration | Days with DAC; much shorter without DAC | Short-acting |
| Key research | Human study of prolonged GH/IGF-1 rise (DAC) | Animal studies of selective GH release |
DAC vs no DAC
DAC (Drug Affinity Complex) lets CJC-1295 bind to albumin in the blood. In healthy adults, CJC-1295 with DAC raised GH and IGF-1 for several days after a single administration (Teichman et al., 2006), and GH continued to be released in pulses rather than continuously (Ionescu & Frohman, 2006).
Without DAC, the peptide (also called modified GRF 1-29) is cleared much faster, which is the form typically paired with ipamorelin.
Why the blend is studied
Ipamorelin was characterised as a selective GH secretagogue that did not markedly raise ACTH or cortisol in animal studies (Raun et al., 1998). Combining a GHRH analog with a ghrelin mimetic lets researchers stimulate both GH pathways at once.
Frequently asked questions
What is the difference between CJC-1295 and ipamorelin?
CJC-1295 is a GHRH analog acting on the GHRH receptor; ipamorelin acts on the ghrelin receptor GHS-R1a.
Which CJC-1295 is in the CJC-1295/Ipamorelin blend?
Our blend uses CJC-1295 without DAC. CJC-1295 with DAC is sold separately.
What does DAC do?
DAC lets CJC-1295 bind albumin, extending its activity from minutes to days in published human data.
Can I buy CJC-1295 and ipamorelin separately?
Yes. CJC-1295 with DAC and ipamorelin are sold individually, and CJC-1295 (no DAC) + ipamorelin is sold as a blend, for laboratory research only. See our research peptides guide (/learn/research-peptides) for how to compare suppliers and read test documents.
How should the CJC-1295/ipamorelin blend be stored?
Keep lyophilised vials cold, dry and away from light; refrigerate reconstituted solutions. See our research peptides guide (/learn/research-peptides) for how to compare suppliers and read test documents.
Is this product for human use?
No. PeptidesDirect sells this compound for laboratory research only. It is not a drug, food or cosmetic and is not for human or veterinary use. This page summarises published research and is not dosing or medical guidance.
References
- Teichman SL, et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006. PubMed 16352683
- Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006. PubMed 17018654
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998. PubMed 9849822
Research compounds
Related guides
Research Use Only. Not for human or veterinary use. Not dosing or medical guidance.
