Semaglutide (GLP-1) 5mg / 10mg

4.9 stars

$45.00$68.00

5mg
10mg

Earn up to 68 Points.

SKU: N/A Category:

Size Options: 10mg /5mgComposition: Fragment 176-191 Form: Lyophilized Powder Purity: >99% Product Code: P-FRAG176-191

Enjoy Complimentary Shipping on Orders Over $200

Receive a Free 30ml Bac Water with Orders Over $200

Discounts Available for Larger Quantities

Description

Semaglutide (GLP-1) 5mg / 10mg

Semaglutide is a synthetic analog of the glucagon-like peptide-1 (GLP-1). GLP-1 is a naturally occurring peptide hormone consisting of 30 amino acids. Its primary function is to enhance insulin production, lower blood sugar levels, and preserve pancreatic beta cells by stimulating insulin gene transcription. Moreover, it has the potential to slow down gastric emptying, which may lead to reduced appetite. GLP-1 can have significant effects on vital organs such as the heart, kidneys, lungs, and liver. As a GLP-1 receptor agonist, semaglutide may reduce insulin and glucose levels while curbing appetite, potentially resulting in weight loss.

The peptide is thought to exert its effects through various pathways, which may include:

  • Binding to GLP-1 receptors, promoting insulin release in a glucose-dependent manner.
  • Suppressing glucagon release and inhibiting the liver’s production of glucose.
  • Enhancing pancreatic beta cell function, thereby improving the proinsulin-to-insulin ratio.
  • Delaying gastric motility, which can contribute to a reduction in appetite.

Semaglutide Peptide and Incretin

Incretins are a group of hormones released by the gastrointestinal tract in response to meal intake, with the potential to lower blood glucose levels. GLP-1 receptors are present on the surface of pancreatic beta cells, and when Semaglutide binds to these receptors, it may stimulate insulin secretion and help regulate blood glucose levels. As explained by J.J. Holst, GLP-1’s primary actions include stimulating insulin secretion (acting as an incretin hormone) and inhibiting glucagon secretion, thereby helping to control post-meal blood sugar fluctuations. Semaglutide, as a GLP-1 receptor agonist, may play a role in incretin hormone production and the regulation of blood sugar levels.

Semaglutide Peptide and Pancreatic Beta Cells

An experiment involving non-obese diabetic mouse models administered Semaglutide in combination with lisofylline (a compound suppressing autoimmunity) and exedin-4 (a compound promoting beta cell proliferation) suggested that the peptide may support the growth of pancreatic beta cells and protect them from apoptosis. Additionally, Semaglutide was proposed to help maintain optimal glucose levels in the body even 145 days after discontinuation in the test subjects.

Semaglutide Peptide and Appetite

GLP-1 receptor agonists like Semaglutide may potentially delay gastric motility, leading to increased satiety and reduced appetite. Animal studies indicated that when these peptides were administered to the brain, they could decrease the urge to consume food and curb food intake.

Semaglutide and Neurological Potential

The GLP-1 receptor, known as GLP-1R, is believed to play a significant role in enhancing cognitive functions. Both GLP-1 and GLP-1R are expressed in brain cells, and when GLP-1R is activated, it may improve cognitive and learning abilities. According to Mathew J. During et al., “Systemic administration of GLP-1 receptor agonists in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons. Brain GLP-1R represents a promising new target for cognitive-enhancing and neuroprotective agents.” These findings suggest potential applications of the peptide in neurological research.

Semaglutide and Cardiovascular Receptors

GLP-1 receptors are distributed throughout the cardiovascular system, and their activation may help maintain cardiac function. GLP-1 and its agonists may contribute to optimal blood pressure regulation and a reduction in left ventricular diastolic pressure, preventing hypertrophy, cardiac issues, and heart attacks. Semaglutide may enhance glucose uptake by heart muscles, potentially reversing weakness and ischemia in post-myocardial infarction scenarios.

CAS Number910463-68-2
PubChem CID 56843331
Molecular Weight4114 g/mol
Molecular FormulaC187H291N45O59
SynonymsSemaglutide, Oxempic, Rybelsus, NN9535
Storage (Lyophilized)

At 39 Fahrenheit: 2 years

At -4 Fahrenheit: 3 years

Semaglutide (GLP-1) 5mg / 10mg

Semaglutide is a synthetic analog of the glucagon-like peptide-1 (GLP-1). GLP-1 is a naturally occurring peptide hormone consisting of 30 amino acids. Its primary function is to enhance insulin production, lower blood sugar levels, and preserve pancreatic beta cells by stimulating insulin gene transcription. Moreover, it has the potential to slow down gastric emptying, which may lead to reduced appetite. GLP-1 can have significant effects on vital organs such as the heart, kidneys, lungs, and liver. As a GLP-1 receptor agonist, semaglutide may reduce insulin and glucose levels while curbing appetite, potentially resulting in weight loss.

The peptide is thought to exert its effects through various pathways, which may include:

  • Binding to GLP-1 receptors, promoting insulin release in a glucose-dependent manner.
  • Suppressing glucagon release and inhibiting the liver’s production of glucose.
  • Enhancing pancreatic beta cell function, thereby improving the proinsulin-to-insulin ratio.
  • Delaying gastric motility, which can contribute to a reduction in appetite.

Semaglutide Peptide and Incretin

Incretins are a group of hormones released by the gastrointestinal tract in response to meal intake, with the potential to lower blood glucose levels. GLP-1 receptors are present on the surface of pancreatic beta cells, and when Semaglutide binds to these receptors, it may stimulate insulin secretion and help regulate blood glucose levels. As explained by J.J. Holst, GLP-1’s primary actions include stimulating insulin secretion (acting as an incretin hormone) and inhibiting glucagon secretion, thereby helping to control post-meal blood sugar fluctuations. Semaglutide, as a GLP-1 receptor agonist, may play a role in incretin hormone production and the regulation of blood sugar levels.

Semaglutide Peptide and Pancreatic Beta Cells

An experiment involving non-obese diabetic mouse models administered Semaglutide in combination with lisofylline (a compound suppressing autoimmunity) and exedin-4 (a compound promoting beta cell proliferation) suggested that the peptide may support the growth of pancreatic beta cells and protect them from apoptosis. Additionally, Semaglutide was proposed to help maintain optimal glucose levels in the body even 145 days after discontinuation in the test subjects.

Semaglutide Peptide and Appetite

GLP-1 receptor agonists like Semaglutide may potentially delay gastric motility, leading to increased satiety and reduced appetite. Animal studies indicated that when these peptides were administered to the brain, they could decrease the urge to consume food and curb food intake.

Semaglutide and Neurological Potential

The GLP-1 receptor, known as GLP-1R, is believed to play a significant role in enhancing cognitive functions. Both GLP-1 and GLP-1R are expressed in brain cells, and when GLP-1R is activated, it may improve cognitive and learning abilities. According to Mathew J. During et al., “Systemic administration of GLP-1 receptor agonists in wild-type animals prevents kainate-induced apoptosis of hippocampal neurons. Brain GLP-1R represents a promising new target for cognitive-enhancing and neuroprotective agents.” These findings suggest potential applications of the peptide in neurological research.

Semaglutide and Cardiovascular Receptors

GLP-1 receptors are distributed throughout the cardiovascular system, and their activation may help maintain cardiac function. GLP-1 and its agonists may contribute to optimal blood pressure regulation and a reduction in left ventricular diastolic pressure, preventing hypertrophy, cardiac issues, and heart attacks. Semaglutide may enhance glucose uptake by heart muscles, potentially reversing weakness and ischemia in post-myocardial infarction scenarios.

CAS Number910463-68-2
PubChem CID 56843331
Molecular Weight4114 g/mol
Molecular FormulaC187H291N45O59
SynonymsSemaglutide, Oxempic, Rybelsus, NN9535
Storage (Lyophilized)

At 39 Fahrenheit: 2 years

At -4 Fahrenheit: 3 years

Additional information
Size

5mg, 10mg

Related products