Epitalon (20mg)

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Size Options: 20mg Composition: Fragment 176-191 Form: Lyophilized Powder Purity: >99% Product Code: P-FRAG176-191

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Description

Epitalon (20mg)

Epitalon, also referred to as AEDG peptide, tetrapeptide Epitalon, Epithalon, or Epithalone, has emerged as a subject of intense research interest due to its potential to modulate the functions of the brain, the pineal gland, and the retina of the eye. Extensive studies into this peptide have sparked diverse research avenues, ranging from its potential to enhance sleep by stimulating the pineal gland and increasing melatonin production to its purported role in promoting telomerase generation, exhibiting robust antioxidant properties, and potentially extending the functional longevity of the retina.

Recent advancements in scientific technology have facilitated the development of methods to synthesize intricate peptide compounds derived from various tissue extracts. Among these tissues, the pineal gland naturally produces a peptide known as ‘Epithalamin.’ Epithalamin has been suggested to possess the capacity to augment melatonin production, enhance immunological responses, combat carcinogenesis in rodent models, and restore reproductive function in aged animals. Clinical studies have reaffirmed these effects of the naturally occurring peptide. Capitalizing on these strides in scientific understanding, researchers have successfully synthesized a peptide analogous to Epithalamin, aptly named ‘Epitalon.’ Epitalon draws inspiration from peptides naturally occurring in both the pineal gland and the retina of the eye.

Overview 

Epitalon, also recognized as Epithalon or Epithalone, represents a synthetic tetrapeptide identified as AEDG peptide, comprising the amino acids Ala-Glu-Asp-Gly. This peptide has raised significant interest due to its potential to emulate the actions of Epithalamin, a naturally occurring substance. The ensuing sections delve deeper into the mechanisms and research findings associated with this intriguing peptide.

Research and Clinical Studies

Epitalon Peptide and Longevity

Epitalon has been the subject of intriguing research into its potential effects on longevity. Recent studies suggest that this peptide interacts with histones HI/6 and HI/3, found at distinct tissue sites, which, in turn, influence DNA function. This interaction potentially leads to a significant increase (approximately 1.6 to 1.8 times) in neurogenic differentiation during gene transcription. Key markers such as Nestin, Beta Tubulin III, and Doublecortin are implicated in this process. The outcome of this enhanced neurogenic differentiation, coupled with heightened protein synthesis, particularly in retinal and ligament stem cells, holds the promise of improved functionality in these vital cellular components.

Epitalon Peptide and Anti-Aging

In the quest to understand the mechanisms of anti-aging, researchers have extensively explored various synthetic peptides, including Epitalon. Studies have aimed to assess the peptide’s impact on critical aspects of aging, such as cell proliferation, cellular regeneration, cellular apoptosis, and matrix modeling. Notably, Epitalon’s potential to inhibit the synthesis of MM-9, an enzyme that typically increases with age, has been highlighted. Furthermore, Epitalon has shown promise in promoting cell proliferation and cellular regeneration processes, which often decline with advancing age.

Epithalon Peptide and Fetal Studies

Fetal studies involving Epitalon have shed light on its remarkable potential to rejuvenate aging cells. These investigations focused on fetal fibroblastic cells isolated from 24-week-old fetuses. Interestingly, these cells, despite their potential for regeneration, exhibited a loss of proliferative capacity at the 34th passage. Moreover, they displayed significantly reduced telomere sizes compared to their original state during the 10th passage. However, when Epitalon was introduced into these aging cells, it triggered a noteworthy response. The peptide stimulated the elongation and restoration of telomeres, leading to an increase in size and the restoration of their normal dimensions. This telomere lengthening phenomenon resulted in an extraordinary extension of the cell cycle, allowing for ten additional cell divisions compared to control cells. This groundbreaking discovery suggests that Epitalon has the potential to overcome the Hayflick limit, a critical barrier to cell division, thereby offering a means of significant cellular rejuvenation.

Epitalon Peptide and Lymphocytic Cells

The role of Epitalon in enhancing the functionality of lymphocytic cells, vital components of the immune system, has been a subject of clinical study. In an investigation involving subjects aged between 76 and 80 years, lymphocytic cells were isolated and cultured to determine Epitalon’s effects on ribosomal cell activity and its influence on denaturation and polymorphism of heterochromatin. The results were compelling. Epitalon administration appeared to activate ribosomal genes and induce decondensation of heterochromatin. Consequently, this decondensation facilitated the release of genes that had been suppressed due to aging-related changes in chromosomal regions. These findings suggest that Epitalon holds the potential to modify chromosome regions within aging cells, activate chromatin, and restore suppressed or delayed cellular activities—a rejuvenating prospect, especially for geriatric subjects.

Epitalon Peptide and Anti-Mutagenic Action

Genomic stability is paramount for healthy aging. Epitalon has been explored for its ability to maintain genomic integrity by inhibiting chromosomal aberrations—a form of anti-mutagenic action. A study conducted in 2011 employed three different mouse models, including SAMP-1 female mice with accelerated aging and wild rats SAMR-1 and SHR (both female mice). Notably, SAMP-1 mice with accelerated aging exhibited almost twice the incidence of chromosomal aberrations in their bone marrow compared to the other two models. However, upon Epitalon administration at the age of 2 months, all three models displayed a reduction in chromosomal aberrations, with the most significant decrease observed in SAMP-1 mice. Importantly, the study found that combining Epitalon with melatonin at night did not diminish its anti-mutagenic potential. These findings underscore Epitalon’s promise in protecting against age-related genomic instability and its associated health risks.

Epitalon Peptide and Anti-Cancer Properties

Cancer is a formidable health concern that becomes increasingly prevalent with age. Epitalon has emerged as a potential ally in the fight against cancer, particularly in inhibiting metastasis and tumor growth. In a study involving one-year-old female (C3H/He) mice with tumors in their reproductive organs (mammary glands and ovaries), Epitalon’s impact was evident. Tumors in the mammary glands comprised various invasive ductal carcinogenic cell variants, while ovarian tumors were granulosa cell tumors. The mice were divided into control and experimental groups, with Epitalon administered five times a week. The results were promising. In the control group, three out of nine mice exhibited metastasis and an increase in tumor cell numbers. In contrast, the mice treated with Epitalon experienced a reduction in tumor cell numbers, demonstrating the peptide’s potential to inhibit metastasis and impede tumor cell cycle and growth. These findings highlight Epitalon’s anti-metastatic properties and its potential as a novel approach to cancer therapy.

Epitalon Peptide and Research in Hypophysectomized Birds

The thymus gland plays a pivotal role in immune function, and its involution with age is well-documented. Epitalon has been studied for its ability to restore thymus gland morphology. In a study involving hypophysectomized birds, both young and old, Epitalon administration led to significant improvements. Remarkably, the restoration of thymus gland morphology was observed in all birds, regardless of age. The most notable enhancements were evident in birds, predominantly chickens, that had undergone neonatal hypophysectomy before receiving Epitalon. These findings suggest that Epitalon may hold promise in rejuvenating the thymus gland, potentially enhancing immune function—a critical factor in healthy aging.

Epitalon Peptide and Melatonin Levels

Melatonin, essential for regulating sleep patterns, tends to decline with age, contributing to sleep disturbances. Epitalon’s impact on melatonin levels has been investigated in aging monkeys and clinical subjects. The study found that Epitalon administration stimulated melatonin production, closely resembling the natural secretion of the pineal gland. As a result, melatonin levels increased, particularly during nighttime hours. This elevation in melatonin levels holds the potential to address sleep-related challenges in elderly individuals, improving overall sleep quality.

Epitalon Peptide and Retinal Cells

Age-related retinal degeneration is a common ailment leading to vision impairment and blindness in older individuals. Epitalon has been explored for its potential to preserve retinal health and even reverse age-related retinal degeneration. A clinical study suggested that when administered to geriatric subjects, Epitalon elevated bioelectric and functional activities in the retina, effectively preserving its morphological structure. This promising outcome was evident in 90% of the subjects treated with Epitalon, offering hope for improved vision and enhanced quality of life in aging individuals.

Epitalon and Geroprotective Properties

Geroprotection, safeguarding against age-related health concerns, is a key focus of longevity research. Epitalon has emerged as a potential geroprotective agent, offering a range of benefits that can promote healthier aging. A comprehensive study involving 266 elderly subjects aged over 60, spanning 6 to 8 years, explored the effects of Epitalon and Thymalin, administered separately or in combination. Both peptides demonstrated the potential to restore fundamental bodily functions in geriatric subjects, encompassing improvements in cardiovascular health, endocrine function, immune responses, and nervous system functionality. Furthermore, metabolic processes and hemostatic activities were normalized, contributing to overall health and vitality. Most notably, the peptide-treated groups exhibited a significant reduction in common geriatric disorders, including acute respiratory disorders, heart diseases, and bone disorders. Importantly, mortality rates in the peptide-treated subjects exhibited substantial reductions, underscoring the potential of Epitalon and Thymalin as interventions for age-related health issues.

CAS Number
PubChem CID
Molecular Weight
Molecular Formula
Synonyms
Storage (Lyophilized) At 39 Fahrenheit: 2 years At -4 Fahrenheit: 3 years

Epitalon (20mg)

Epitalon, also referred to as AEDG peptide, tetrapeptide Epitalon, Epithalon, or Epithalone, has emerged as a subject of intense research interest due to its potential to modulate the functions of the brain, the pineal gland, and the retina of the eye. Extensive studies into this peptide have sparked diverse research avenues, ranging from its potential to enhance sleep by stimulating the pineal gland and increasing melatonin production to its purported role in promoting telomerase generation, exhibiting robust antioxidant properties, and potentially extending the functional longevity of the retina.

Recent advancements in scientific technology have facilitated the development of methods to synthesize intricate peptide compounds derived from various tissue extracts. Among these tissues, the pineal gland naturally produces a peptide known as ‘Epithalamin.’ Epithalamin has been suggested to possess the capacity to augment melatonin production, enhance immunological responses, combat carcinogenesis in rodent models, and restore reproductive function in aged animals. Clinical studies have reaffirmed these effects of the naturally occurring peptide. Capitalizing on these strides in scientific understanding, researchers have successfully synthesized a peptide analogous to Epithalamin, aptly named ‘Epitalon.’ Epitalon draws inspiration from peptides naturally occurring in both the pineal gland and the retina of the eye.

Overview 

Epitalon, also recognized as Epithalon or Epithalone, represents a synthetic tetrapeptide identified as AEDG peptide, comprising the amino acids Ala-Glu-Asp-Gly. This peptide has raised significant interest due to its potential to emulate the actions of Epithalamin, a naturally occurring substance. The ensuing sections delve deeper into the mechanisms and research findings associated with this intriguing peptide.

Research and Clinical Studies

Epitalon Peptide and Longevity

Epitalon has been the subject of intriguing research into its potential effects on longevity. Recent studies suggest that this peptide interacts with histones HI/6 and HI/3, found at distinct tissue sites, which, in turn, influence DNA function. This interaction potentially leads to a significant increase (approximately 1.6 to 1.8 times) in neurogenic differentiation during gene transcription. Key markers such as Nestin, Beta Tubulin III, and Doublecortin are implicated in this process. The outcome of this enhanced neurogenic differentiation, coupled with heightened protein synthesis, particularly in retinal and ligament stem cells, holds the promise of improved functionality in these vital cellular components.

Epitalon Peptide and Anti-Aging

In the quest to understand the mechanisms of anti-aging, researchers have extensively explored various synthetic peptides, including Epitalon. Studies have aimed to assess the peptide’s impact on critical aspects of aging, such as cell proliferation, cellular regeneration, cellular apoptosis, and matrix modeling. Notably, Epitalon’s potential to inhibit the synthesis of MM-9, an enzyme that typically increases with age, has been highlighted. Furthermore, Epitalon has shown promise in promoting cell proliferation and cellular regeneration processes, which often decline with advancing age.

Epithalon Peptide and Fetal Studies

Fetal studies involving Epitalon have shed light on its remarkable potential to rejuvenate aging cells. These investigations focused on fetal fibroblastic cells isolated from 24-week-old fetuses. Interestingly, these cells, despite their potential for regeneration, exhibited a loss of proliferative capacity at the 34th passage. Moreover, they displayed significantly reduced telomere sizes compared to their original state during the 10th passage. However, when Epitalon was introduced into these aging cells, it triggered a noteworthy response. The peptide stimulated the elongation and restoration of telomeres, leading to an increase in size and the restoration of their normal dimensions. This telomere lengthening phenomenon resulted in an extraordinary extension of the cell cycle, allowing for ten additional cell divisions compared to control cells. This groundbreaking discovery suggests that Epitalon has the potential to overcome the Hayflick limit, a critical barrier to cell division, thereby offering a means of significant cellular rejuvenation.

Epitalon Peptide and Lymphocytic Cells

The role of Epitalon in enhancing the functionality of lymphocytic cells, vital components of the immune system, has been a subject of clinical study. In an investigation involving subjects aged between 76 and 80 years, lymphocytic cells were isolated and cultured to determine Epitalon’s effects on ribosomal cell activity and its influence on denaturation and polymorphism of heterochromatin. The results were compelling. Epitalon administration appeared to activate ribosomal genes and induce decondensation of heterochromatin. Consequently, this decondensation facilitated the release of genes that had been suppressed due to aging-related changes in chromosomal regions. These findings suggest that Epitalon holds the potential to modify chromosome regions within aging cells, activate chromatin, and restore suppressed or delayed cellular activities—a rejuvenating prospect, especially for geriatric subjects.

Epitalon Peptide and Anti-Mutagenic Action

Genomic stability is paramount for healthy aging. Epitalon has been explored for its ability to maintain genomic integrity by inhibiting chromosomal aberrations—a form of anti-mutagenic action. A study conducted in 2011 employed three different mouse models, including SAMP-1 female mice with accelerated aging and wild rats SAMR-1 and SHR (both female mice). Notably, SAMP-1 mice with accelerated aging exhibited almost twice the incidence of chromosomal aberrations in their bone marrow compared to the other two models. However, upon Epitalon administration at the age of 2 months, all three models displayed a reduction in chromosomal aberrations, with the most significant decrease observed in SAMP-1 mice. Importantly, the study found that combining Epitalon with melatonin at night did not diminish its anti-mutagenic potential. These findings underscore Epitalon’s promise in protecting against age-related genomic instability and its associated health risks.

Epitalon Peptide and Anti-Cancer Properties

Cancer is a formidable health concern that becomes increasingly prevalent with age. Epitalon has emerged as a potential ally in the fight against cancer, particularly in inhibiting metastasis and tumor growth. In a study involving one-year-old female (C3H/He) mice with tumors in their reproductive organs (mammary glands and ovaries), Epitalon’s impact was evident. Tumors in the mammary glands comprised various invasive ductal carcinogenic cell variants, while ovarian tumors were granulosa cell tumors. The mice were divided into control and experimental groups, with Epitalon administered five times a week. The results were promising. In the control group, three out of nine mice exhibited metastasis and an increase in tumor cell numbers. In contrast, the mice treated with Epitalon experienced a reduction in tumor cell numbers, demonstrating the peptide’s potential to inhibit metastasis and impede tumor cell cycle and growth. These findings highlight Epitalon’s anti-metastatic properties and its potential as a novel approach to cancer therapy.

Epitalon Peptide and Research in Hypophysectomized Birds

The thymus gland plays a pivotal role in immune function, and its involution with age is well-documented. Epitalon has been studied for its ability to restore thymus gland morphology. In a study involving hypophysectomized birds, both young and old, Epitalon administration led to significant improvements. Remarkably, the restoration of thymus gland morphology was observed in all birds, regardless of age. The most notable enhancements were evident in birds, predominantly chickens, that had undergone neonatal hypophysectomy before receiving Epitalon. These findings suggest that Epitalon may hold promise in rejuvenating the thymus gland, potentially enhancing immune function—a critical factor in healthy aging.

Epitalon Peptide and Melatonin Levels

Melatonin, essential for regulating sleep patterns, tends to decline with age, contributing to sleep disturbances. Epitalon’s impact on melatonin levels has been investigated in aging monkeys and clinical subjects. The study found that Epitalon administration stimulated melatonin production, closely resembling the natural secretion of the pineal gland. As a result, melatonin levels increased, particularly during nighttime hours. This elevation in melatonin levels holds the potential to address sleep-related challenges in elderly individuals, improving overall sleep quality.

Epitalon Peptide and Retinal Cells

Age-related retinal degeneration is a common ailment leading to vision impairment and blindness in older individuals. Epitalon has been explored for its potential to preserve retinal health and even reverse age-related retinal degeneration. A clinical study suggested that when administered to geriatric subjects, Epitalon elevated bioelectric and functional activities in the retina, effectively preserving its morphological structure. This promising outcome was evident in 90% of the subjects treated with Epitalon, offering hope for improved vision and enhanced quality of life in aging individuals.

Epitalon and Geroprotective Properties

Geroprotection, safeguarding against age-related health concerns, is a key focus of longevity research. Epitalon has emerged as a potential geroprotective agent, offering a range of benefits that can promote healthier aging. A comprehensive study involving 266 elderly subjects aged over 60, spanning 6 to 8 years, explored the effects of Epitalon and Thymalin, administered separately or in combination. Both peptides demonstrated the potential to restore fundamental bodily functions in geriatric subjects, encompassing improvements in cardiovascular health, endocrine function, immune responses, and nervous system functionality. Furthermore, metabolic processes and hemostatic activities were normalized, contributing to overall health and vitality. Most notably, the peptide-treated groups exhibited a significant reduction in common geriatric disorders, including acute respiratory disorders, heart diseases, and bone disorders. Importantly, mortality rates in the peptide-treated subjects exhibited substantial reductions, underscoring the potential of Epitalon and Thymalin as interventions for age-related health issues.

CAS Number 
PubChem CID 
Molecular Weight 
Molecular Formula 
Synonyms 
Storage (Lyophilized)

At 39 Fahrenheit: 2 years

At -4 Fahrenheit: 3 years

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